Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome

Abstract

Introduction: The aim of this study was to evaluate the changes of some biomarkers in streptozotocin-induced diabetic rats following the administration of pure extract of Cynodon dactylon. Materials & Methods: In this study, after dividing 50 rats into five groups and induction of diabetes mellitus in four groups, pure extract of Cynodon dactylon was administered at 150, 300, and 450 mg/kg/day concentrations to three diabetic groups for three months. The positive control group (diabetic group without Cynodon dactylon administarion) along with negative control group (non-diabetic group) did not receive any extract. Afterwards, some biomarkers along with plasma adenosine deaminase (ADA) activity were assessed in all the groups. Findings: The results showed a significant increase in all the inflammatory markers, including ADA Hcy, and cTnI (P≤0.01) and a significant reduction in marker of tissue damage, gelsolin (GLS), (P≤0.01) in the positive control group compared with the control group. We also found a significant decrease in these parameters (P≤0.01) and a significant increase in marker of tissue damage (GLS) following the administration of 450 mg/kg of the extract compared to the positive control and negative control groups. Discussion & Conclusions: It can be concluded that the extract of Cynodon dactylon, especially at the concentration of 450 mg/kg of body weight, can significantly reduce cardiovascular and inflammatory biomarkers and elevate GLS concentration in diabetic rats.