Plasma cell lesions within the oral tissues: Immunoperoxidase staining of routinely fixed and processed tissue

Abstract

Multiple and solitary myeloma of bone and extramedullary plasmacytoma are often associated with primary or secondary involvement of the oral cavity. With conventional histologic techniques, differentiation of these neoplastic proliferations from the dense plasma cell infiltrates commonly accompanying inflammatory processes in the oral tissues can present a diagnostic problem. This article presents eight cases of plasma cell or plasma cell-like lesions within the oral tissues to illustrate the way in which immunoperoxidase techniques on routinely fixed and embedded tissues can aid histologic methods.