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Abstract
Multiple myeloma (MM) is a plasma cell malignancy characterized by chromosomal instabilities (CIN), including complex cytogenetic and molecular abnormalities. Cell-free DNA (cfDNA) offers the potential for minimally invasive genome-wide profiling of tumor alterations in monitoring tumor burden without tumor biopsy and may be associated with cancer precision medicine and patient prognosis. The better response is associated with improved overall survival (OS) in MM, but data on early response at treatment two cycle to predictor the prognosis are limited.
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