Abstract
Abstract Plasma cells are terminally differentiated B cells that produce and secrete profuse amounts of antibodies. Plasma cell differentiation involves an increase in exocytic pathway components and expansion of the endoplasmic reticulum (ER) in order to accommodate high-rate immunoglobulin synthesis. ER expansion requires membrane biogenesis, a process that requires phospholipids. Increased phospholipid synthesis is dependent upon a sufficient supply of fatty acids. We have found that de novo fatty acid biosynthesis increases in CH12 B cells differentiating in response to lipopolysaccharide (LPS). Increased fatty acid biosynthesis correlates with upregulation of acetyl CoA carboxylase (ACC) and fatty acid synthase (FAS), enzymes that catalyze the formation of fatty acids. Further investigation will shed light into mechanisms that regulate lipid synthesis and ER expansion in differentiating plasma cells. Supported by NIH-GM61970 and NIH-T32 A1007508
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