Abstract
The behavior and plasma levels of norepinephrine (NE) and epinephrine (EPI) were compared in sham-operated (SO) and adrenal demedullated (AD) rats during 5 min of footshock stress. In some rats, bretylium tosylate (BRET) was administered to block release of NE from sympathetic nerves. Stress-induced increments in plasma NE and EPI were greater in SO than in AD rats although the behavioral responses to stress of the two groups did not differ. However, suppression of NE release by BRET was attended by decreased behavioral responses to stress as well as significant reductions in plasma NE but not EPI.
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