Abstract
Patients with end-stage chronic renal failure on maintenance hæmodialysis treatment show both a progression and an increased incidence of metabolic bone disease and soft-tissue calcification. The biochemical variables associated with calcium homœostasis have been measured in a group of 80 patients with end-stage chronic renal failure on hæmodialysis. The patients were classified into two groups, those with and those without disordered calcium homœostasis, on the basis of a radiological survey. There were no significant differences in the biochemical variables measured between the two groups, except for plasma-alkaline-phosphatase activity, and even this was of limited discriminatory value. The patients with disordered calcium homœostasis had been receiving maintenance hæmodialysis treatment over significantly more months than had the other patients. It is proposed that hæmodialysis itself may play an important role in the ætiology of the progressive metabolic bone disease and extraosseous calcification in patients with end-stage chronic renal failure receiving this treatment.
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