Plasma C1q/TNF-Related Protein-3 (CTRP-3) and High-Mobility Group Box-1 (HMGB-1) Concentrations in Subjects with Prediabetes and Type 2 Diabetes.

Huili Wei,Huacong Deng,Hua Qu,Hang Wang

doi:10.1155/2016/9438760

Abstract

Aims. To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM). Methods. 224 eligible participants were included. The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured. All participants were divided into three groups: normal glucose tolerance (NGT, n = 62), pre-DM (n = 111), and nT2DM group (n = 56). Results. Plasma CTRP-3 concentrations were significantly lower in subjects with pre-DM and nT2DM than that of the NGT group, while plasma HMGB-1 levels were higher in pre-DM and nT2DM group compared with the NGT group (P < 0.05). A multiple linear regression analysis showed both plasma CTRP-3 and HMGB-1 concentrations were independently associated with homeostasis model assessment for insulin resistance (HOMA-IR) and interleukin-6 (IL-6) (P < 0.05 for all). Further multiple logistical regression analyses revealed that both plasma CTRP-3 and HMGB-1 levels were significantly associated with pre-DM and nT2DM after adjusting for several confounders (P < 0.001 for all). Conclusions. Circulating CTRP-3 and HMGB-1 concentrations might be promising biomarkers to predict prediabetes and type 2 diabetes.

Highlights

Since the dramatic changes in lifestyle worldwide, diabetes has become one of the most common metabolic disorders globally
We aim to explore the association of plasma C1q/tumor necrosis factor- (TNF-)related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) with newly diagnosed pre-DM and T2DM
Subjects in newly diagnosed T2DM (nT2DM) group had higher levels of body mass index (BMI), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) compared with the pre-DM group

Summary

Introduction

Since the dramatic changes in lifestyle worldwide, diabetes has become one of the most common metabolic disorders globally. In 2013, the International Diabetes Federation (IDF) reported 382 million people with diabetes and the number was projected to reach 592 million by 2035 [1]. Of note, another piece of data from IDF revealed 45.8% or 174.8 million of undiagnosed diabetes in all diabetes cases globally [2]. As an intermediate state between normal glucose tolerance (NGT) and type 2 diabetes (T2DM), pre-DM is characterized by insulin resistance and impaired insulin secretion [4, 5]. It is estimated that up to 70% of individuals with pre-DM will progress to diabetes at a rate of 5–10% per year [7]. In China, the age-adjusted prevalence of pre-DM is 15.5%, accounting for 148.2 million people with pre-DM [10]

Methods

Results

Conclusion