Abstract
A dietary supplement of fish paste, when compared with meat paste, has been shown to lower pseudo(butyryl)cholinesterase activity in the plasma of humans [1]. In rats, dietary fish oil produces increased activities of plasma butyrylcholinesterase [2]. This implies that either rats and man respond differently to fish oil or that the observed effect of the fish paste [1] is not related to its oil content. One hypothesis that may be advanced is that fish protein lowers butyrylcholinesterease activity and thus counteracts the influence of the fish oil. In the course of a study with rats on the effects of dietary fish proteins on cholesterol metabolism of rats, we had the opportunity to test this hypothesis. In addition to plasma butyrylcholinesterase, we also measured plasma esterase-1 (ES-1).
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