Abstract
We have previously identified five candidate proteins (matrix metallopeptidase 9 (MMP9), phenylalanyl-TRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin Type 9 (PCSK9)) as potential biomarkers for bipolar II disorder (BD-II). These candidate proteins have been associated with neuroprotective factors (BDNF) and inflammatory factors (cytokines, C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α)). However, the correlations between these proteins with plasma BDNF and inflammatory factors remain unknown. We recruited a total of 185 patients with BD-II and 186 healthy controls. Plasma levels of candidate proteins, BDNF, cytokines (TNF-α, CRP, and interleukin-8 (IL-8)) were assessed from each participant. The correlations between levels of candidate proteins, BDNF, and cytokines were analyzed. In the BD-II group, we found that the level of FARSB was positively correlated with the BDNF level (r = 0.397, p < 0.001) and IL-8 (r = 0.320, p < 0.001). The CA-1 level positively correlated with IL-8 (r = 0.318, p < 0.001). In the control group, we found that the FARSB level positively correlated with the BDNF level (r = 0.648, p < 0.001). The CA-1 level positively correlated with TNF-α (r = 0.231, p = 0.002), while the MMP-9 level positively correlated with the CRP level (r = 0.227, p = 0.002). Our results may help in clarifying the underlying mechanism of these candidate proteins for BD-II.
Highlights
Bipolar II disorder (BD-II), one subtype of bipolar disorder, imposes a huge socioeconomic burden on the patient [1,2]
We found significantly increased plasma proteins including PRDX2, CA-1, FARSB, MMP9, and PCSK9 and increased plasma levels of been associated with neuroprotective factors (BDNF), C-reactive protein (CRP), and IL-8 in patients with
We found significant correlations between plasma levels of candidate proteins of BD-II and cytokine and BDNF levels; the observed correlations differed between patients with BD-II and the controls
Summary
Bipolar II disorder (BD-II), one subtype of bipolar disorder, imposes a huge socioeconomic burden on the patient [1,2]. As BD-II is currently solely diagnosed through clinical presentation and assessment of the patient’s history, the diagnosis is frequently delayed or missed. The discovery of clinically applicable and reliable biomarkers for BD-II would assist prompt diagnosis and lead to more effective treatment. Proteomics, the study of the identification and quantitative analysis of protein expression in an organism or system, has been proposed as a promising way to identify novel protein biomarkers for certain diseases [3]. We have previously identified candidate protein biomarkers for BD-II including PRDX2, CA-1, FARSB, MMP9, and PCSK9 [4]. The combination of these five candidate proteins was found to be able to predict the diagnosis of BD-II with good
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