Abstract
The role of Renin-Angiotensin-System (RAS) in the pathogenesis of preeclampsia and eclampsia is still unclear. Our aim was to investigate plasma angiotensin II concentration [Ang II] in women with normotensive pregnancies (NP, n=22) and severe preeclampsia in use of magnesium sulfate (SPE, n=29). Despite no difference between the groups (SPE: 47.8pg/ml vs NP: 39.7pg/ml, p=0.195), lower maternal age (p=0.007) and primigravida (p=0.028) were associated with lower [Ang II]. Plasma [Ang II] increased over the 24h of magnesium sulfate administration (r=0.48, p=0.009). Our findings suggest that RAS may be involved with the mechanism of magnesium protection against eclamptic seizure.
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