Abstract
Plasma and tissue lipid peroxide levels were examined in spontaneously diabetic Chinese hamsters (CHA colony) to elucidate the relationship between lipid peroxides and diabetes mellitus. The animals were divided into three groups: group A with severe diabetes, group B with moderate diabetes and group C without diabetes. The plasma lipid peroxide level of groups A and B was significantly higher than that of group C. This level showed significant positive correlations with fasting plasma glucose and lipid levels, but a significant negative correlation with the non-fasting plasma insulin level. The lipid peroxide contents of the liver and aorta of group A were significantly higher than those of group C. We conclude that the plasma lipid peroxide level increases in these diabetic hamsters with the advance of hypoinsulinemia, hyperglycemia, and hyperlipidemia and that its content in the liver and aorta is also increased in these animals.
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