Plasma and synovial fluid connective tissue growth factor levels are correlated with disease severity in patients with knee osteoarthritis

Abstract

Background: Connective tissue growth factor (CTGF) has been implicated in development of osteoarthritis (OA).Objective: To determine the correlation between plasma and synovial fluid CTGF levels and the severity in knee osteoarthritis patients.Methods: A total of 100 subjects were recruited into this study (75 OA patients and 25 controls). CTGF concentrations in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay.Results: Plasma and synovial fluid CTGF concentrations were correlated with radiographic severity. There was a positive correlation between plasma and synovial fluid CTGF levels.Conclusion: CTGF could be useful for monitoring the severity and progression of OA.