Abstract
Plasma and red blood cell choline concentrations have been suggested as possible peripheral markers of brain cholinergie dysfunction in various human diseases such as major affective disorders, tardive dyskinesia, Tourette’s syndrome and senile dementia of the Alzheimer’s type (1, 2, 4–8, 10). The present study was initiated to explore these possible relationships in normal human volunteers and patients of similar age. The patients were diagnosed as having tardive dyskinesia or dementia of the Alzheimer’ s type. These patients were relatively old and their diets were difficult to control. Therefore, additional studies were done in rats and monkeys of various age groups where dietary factors could be held constant. The results obtained indicate that plasma and red blood cell choline levels do not correlate with brain dysfunction in either humans or monkeys. However, in these same species, with increasing age, plasma choline levels increase. Interestingly, increased plasma choline was not observed in aging rats.
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