Abstract
Plasma and erythrocyte sodium (Na +), total and free (ultrafiltrable) plasma magnesium (Mg 2+) as well as erythrocyte magnesium were measured in patients with affective disorders and in healthy control subjects. Depressed and manic patients had higher total plasma Mg 2+ than did hospitalized healthy control subjects, but concentrations of ultrafiltrable Mg 2+ did not differ. Although erythrocyte Mg 2+ was significantly elevated in the depressed subjects in comparison with that found in the non-hospitalized healthy controls, this difference was not seen between the depressives and the hospitalized healthy controls. Depressed, manic or healthy control subjects did not differ with respect to either plasma or erythrocyte Na + concentrations. These studies do not demonstrate any physiologically important abnormality of Mg 2+ or Na + metabolism in depressed or manic patients.
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