Abstract
Diaryl o-( α-hydroxy)tolyl phosphates are cyclized with liberation of an aryl group to yield aryl saligenin cyclic phosphates, which usually are potent antiesterase agents. This cyclization is catalyzed by various plasmata, but not by liver homogenate. The cyclizing activity of plasma is associated with the albumin component when this fraction is prepared either by salting-out with ammonium sulfate or by using Cohn's method and ethanol (fraction V). The activity of the cyclizing enzyme could not be separated from albumin either by Sephadex G-100 or by DEAE-cellulose column chromatography. p-Nitrophenyl acetate, which is also hydrolyzed by the albumin fraction, inhibits the cyclization of diaryl o-( α-hydroxy)tolyl phosphates.
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