Plasma adiponectin concentration is strongly associated with VLDL‐TG catabolism in postmenopausal women

Abstract

Objective: To investigate associations between plasma adiponectin concentration and VLDL‐TG secretion and catabolism in 30 postmenopausal women.Methods: Plasma adiponectin concentration was measured by ELISA. Insulin sensitivity was assessed by a 2‐h euglycemic‐hyperinsulinemic clamp. Fasting plasma glucose (FPG) and 2‐hour plasma glucose (2hPG) were measured during an OGTT. The VLDL‐TG total secretion rate (TSR) and the VLDL‐TG fractional catabolic rate (FCR) were measured by electron impact ionization gas chromatography‐mass spectrometry. The MIDA approach was used to measure VLDL‐TG TSR following a 10h‐infusion of [1‐13C] acetate and the calculation of VLDL‐TG FCR was based on the monoexponential decrease of TG‐[2H5] glycerol values obtained following the administration of a 2H5‐glycerol bolus.Results: Plasma adiponectin concentration was negatively associated with VLDL‐TG TSR (r=−0.42; p<0.02) and positively with VLDL‐TG FCR (r=0.60; p<0.0005). This latter association remained significant after statistical adjustments for insulin sensitivity, HDL‐C, TG, FPG and 2hPG. In a multivariate model, plasma adiponectin level was the best predictor of VLDL‐TG FCR.Conclusion: Elevated plasma adiponectin concentration is associated with favourable VLDL‐TG metabolism. This study was supported by the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada.