Abstract
Background Adipokines are a group of cytokines or peptides secreted by adipose tissue to exert numerous biological functions. In the present study, we measured the plasma levels of four adipokines (adiponectin, leptin, fatty acid-binding protein 4 (FABP4), and visfatin) in cardiac arrest patients following return of spontaneous circulation (ROSC). Methods Totally, 21 patients who experienced cardiac arrest and successful ROSC with expected survival of at least 48 hours (from January 2016 to December 2017) were consecutively enrolled into this prospective observational clinical study. Of the 21 enrolled patients, ten survived, and other eleven died between 2 days and 6 months post ROSC. Venous blood was drawn at three time points: baseline (<1 hour post ROSC), 2 days post ROSC, and 7 days post ROSC. Plasma concentrations of adiponectin, leptin, FABP4, and visfatin were determined using commercial enzyme-linked immunosorbent assays. Results The plasma visfatin levels at 2 or 7 days post ROSC increased significantly compared with the baseline (P < 0.01), while plasma levels of adiponectin, leptin, and FABP4 did not change. Moreover, plasma visfatin levels in survivors at 2 or 7 days post ROSC were higher than those in nonsurvivors (P < 0.01). Plasma visfatin levels at 2 or 7 days post ROSC were negatively correlated with Acute Physiology and Chronic Health Evaluation (APACHE) II score and time to ROSC. Moreover, receiver operating characteristic curve analysis showed that the plasma visfatin levels at 2 or 7 days post ROSC were good predictors for survival of the patients. Conclusion Elevated plasma visfatin levels may be a marker for better outcome of cardiac arrest patients post ROSC.
Highlights
Cardiac arrest is a major public health problem with substantial mortality and morbidity and affects more than one million people worldwide [1]
Adipokines is a group of cytokines or peptides secreted by adipose tissue, which lies at the central of obesity and adipose tissue dysfunction was proposed as a central mechanism connecting obesity with cardiovascular diseases
Our results showed that plasma visfatin levels post return of spontaneous circulation (ROSC) only elevated in survivors but not in nonsurvivors
Summary
Cardiac arrest is a major public health problem with substantial mortality and morbidity and affects more than one million people worldwide [1]. The circulating levels of adiponectin are reduced in patients with obesity [5], whereas another adipokine leptin levels in the blood are significantly increased in obesity. We measured the plasma levels of four adipokines (adiponectin, leptin, fatty acid-binding protein 4 (FABP4), and visfatin) in cardiac arrest patients following return of spontaneous circulation (ROSC). The plasma visfatin levels at 2 or 7 days post ROSC increased significantly compared with the baseline (P < 0:01), while plasma levels of adiponectin, leptin, and FABP4 did not change. Receiver operating characteristic curve analysis showed that the plasma visfatin levels at 2 or 7 days post ROSC were good predictors for survival of the patients.
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