Abstract
Infection can hinder the process of wound healing, so it is important to begin antibacterial treatment quickly after a wound forms. Plasma activated water (PAW) can inactivate a variety of common wound infection bacteria. In this study, we compared the effects of PAW prepared with portable surface discharge plasma equipment and medical alcohol on wound healing in a mouse full-thickness skin wound model. The effectiveness of wound healing processes in mice was ranked accordingly: PAW treatment group > medical alcohol treatment group > control group. In order to further understand the mechanism of PAW in promoting wound healing, we tested the expression levels of the pro-inflammatory factors interleukin (IL)-1β and IL-6, the anti-inflammatory factor IL-10, and vascular endothelial growth factor (VEGF). The results showed that PAW promoted the release of pro-inflammatory factors and anti-inflammatory factors from the wounds in mice, which allowed the mice in the treatment group to transition out of the inflammatory period early and enter the next stage of wound healing. The expression level of VEGF in the wounds of mice in the PAW treatment group was higher, which indicates that the microvessels around the wound in the PAW treatment group proliferated faster, and thus the wound healed faster. PAW biosafety experiments showed that PAW did not significantly affect the appearance, morphology, or tissue structure of internal organs, or blood biochemical indicators in mice. In general, PAW prepared via portable devices is expected to become more widely used given its convenience, affordability, and lack of side effects in promoting wound healing.
Highlights
The formation of wounds involves a certain degree of randomness and universality.When the skin is damaged, the body immediately initiates the relevant biological and chemical processes to help the skin repair the wounded area
We explored the effect of Plasma activated water (PAW) prepared with portable surface discharge plasma equipment on wound healing by constructing full-thickness skin infection wound models on the backs of mice
We first compared the effects of PAW prepared with portable surface discharge plasma equipment and medical alcohol on wound healing
Summary
The formation of wounds involves a certain degree of randomness and universality.When the skin is damaged, the body immediately initiates the relevant biological and chemical processes to help the skin repair the wounded area. Skin wound healing is not a simple, linear process, but a complex dynamic process involving spatial and temporal variables. It can generally be divided into four overlapping periods: hemostasis, inflammatory reaction, cell proliferation, and tissue remodeling [1,2,3]. Due to the complexity of acute wound formation, the wound is susceptible to infection with a variety of aerobic and anaerobic microorganisms. There is a need for new methods to promote wound healing, which have to be simple to operate, affordable, and free of side effects, and must be able to handle different types of wounds caused by a variety of injuries in a more timely and convenient manner
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