Plaque components at coronary sites with focal spasm in patients with variant angina: Virtual histology-intravascular ultrasound analysis

Abstract

We compared the plaque components at coronary sites with focal spasm after ergonovine provocation test in 30 variant angina (VA) patients with those at culprit coronary sites in 32 unstable angina (UA) patients using virtual histology-intravascular ultrasound (VH-IVUS). VH-IVUS classified and color-coded tissue into four major components: fibrotic; fibro-fatty; dense calcium (DC); and necrotic core (NC). Thin-cap fibroatheroma (TCFA) was defined as a NC≥10% of plaque area in at least 3 consecutive frames without overlying fibrous tissue in the presence of ≥40% plaque burden. The lesion site plaque burden was significantly smaller (44.5±10.8% vs. 70.5±13.1%, p<0.001), the plaque volume was significantly smaller (135±118 mm³ vs. 223±160 mm³, p=0.020), the remodeling index was significantly lower (0.90±0.14 vs. 0.97±0.23, p=0.023), and more plaque was hypoechoic with less calcium (87% vs. 56% and 0% vs. 19%, respectively, p=0.033) in VA patients compared with UA patients. The % NC and DC areas were significantly smaller at the minimum lumen site within spasm/culprit lesion (12.9±12.9% vs. 22.3±11.7%, p=0.004, and 6.5±8.0% vs. 12.8±10.8%, p=0.011, respectively), and the % NC and DC volumes were significantly smaller in VA patients compared with UA patients (12.2±10.3% vs. 17.7±8.1%, p=0.025, and 6.4±6.0% vs. 11.8±8.5%, p=0.007, respectively). The TCFA within lesion segments was less frequently observed in VA patients compared with UA patients (13% vs. 53%, p=0.001). VA patients have less plaque, more negative remodeling behavior, more hypoechoic plaque with less calcification, and less NC- and DC-containing lesions and less TCFA lesions compared with UA patients.