Abstract
BackgroundSpray drying is a relatively simple, fast, reproducible and scalable drying technology that is suitable for drying heat-sensitive biopharmaceutical compounds. In view of the rapid progress of nanoencapsulation technologies in the pharmaceutical sector, nano spray drying is used in research to improve the powder formulation and release of active ingredients. The Nano Spray Dryer B-90 of the Swiss company Büchi Labortechnik AG extends the size of the powder particles produced into the nanometer scale with narrow size distributions and high encapsulation efficiency.Area coveredThis study explains the special nano spray drying technology and discusses the influence of the respective process parameters on the powder properties. Applications of nano spray drying for the formulation and encapsulation of active ingredients in PLA/PLGA biopolymers are investigated and discussed. Optimized process parameters for the application of nano spray drying of similar substances are presented.Expert opinionThe analyzed studies show the possibility of producing PLGA particles from approx. 2 μm to below 200 nm by nano spray drying, as well as the encapsulation of various active ingredients in spherical particles and nano-in-nanoparticle composite structures made of PLGA polymers for controlled drug delivery systems. The researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, inflammations, cancer, immune diseases, genetic disorders, the regulation of vasodilatation or the surface coating of medical implants with biocompatible PLGA nanoparticles.
Highlights
PLA/PLGA biopolymersIn the past decades, biopolymers based on lactic acid and glycolic acid and their copolymers have attracted great interest in various medical applications, e.g. as biodegradable implants in surgery with variable mechanical strength, as raw materials for wound closure products that are completely absorbed by the body, or as drug carrier substances for the production of drug delivery systems with excellent biocompatibility, adjustable degradation rate and non-toxicity in humans (Sharma et al 2016).In particular, polylactic acid (PLA) is applied for sutures, stents, dialysis media, drug delivery devices and tissuePoly(lactic-co-glycolic acid) (PLGA) is a copolymer of PLA and polyglycolic acid (PGA) and, in terms of design and performance, the preferred candidate of biodegradable polymers for drug delivery (Sharma et al 2016)
The research results reviewed in this study show the potential of nano spray drying as a relatively new approach and effective technology for encapsulating macromolecular therapeutics in biodegradable PLA/PLGA polymers and their derivatives
The data collected show the possibility of encapsulating different active ingredients in spherical particles and nano-in-nanoparticle composite structures for controlled drug delivery systems
Summary
Biopolymers based on lactic acid and glycolic acid and their copolymers have attracted great interest in various medical applications, e.g. as biodegradable implants in surgery with variable mechanical strength, as raw materials for wound closure products that are completely absorbed by the body, or as drug carrier substances for the production of drug delivery systems with excellent biocompatibility, adjustable degradation rate and non-toxicity in humans (Sharma et al 2016). Poly(lactic-co-glycolic acid) (PLGA) is a copolymer of PLA and polyglycolic acid (PGA) and, in terms of design and performance, the preferred candidate of biodegradable polymers for drug delivery (Sharma et al 2016). Applications of nano spray drying for the formulation and encapsulation of active ingredients in PLA/PLGA biopolymers are investigated and discussed. 2 μm to below 200 nm by nano spray drying, as well as the encapsulation of various active ingredients in spherical particles and nano-in-nanoparticle composite structures made of PLGA polymers for controlled drug delivery systems. The researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, inflammations, cancer, immune diseases, genetic disorders, the regulation of vasodilatation or the surface coating of medical implants with biocompatible PLGA nanoparticles
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