Abstract
Moonlighting proteins are single polypeptide chains capable of executing two or more distinct biochemical and/or biological functions. Here, we describe the development of PlantMP, which is a manually curated online-based database of plant proteins that are known to `moonlight’. The database contains searchable UniProt IDs and names, canonical and moonlighting functions, gene ontology numbers, plant species as well as links to the PubMed indexed articles. Proteins homologous to experimentally confirmed moonlighting proteins from the model plant Arabidopsis thaliana are provided as a separate list of `likely moonlighters’. Additionally, we also provide a list of predicted Arabidopsis moonlighting proteins reported in the literature. Currently, PlantMP contains 110 plant moonlighting proteins, 10 `likely moonlighters’ and 27 `predicted moonlighters’. Organizing plant moonlighting proteins in one platform enables researchers to conveniently harvest plant-specific raw and processed data such as the molecular functions, biological roles and structural features essential for hypothesis formulation in basic research and for biotechnological innovations.
Highlights
Moonlighting proteins are single polypeptide chains capable of executing two or more distinct biochemical and/or biological functions
Moonlighting functions of proteins are often discovered by serendipity, the creation of moonlighting protein databases such as MoonProt [10] and MultitaskProtDB [11] to pool together this class of proteins especially given that they are increasingly common and have been implicated in human diseases [9]
Moonlighting plant proteins in the PlantMP database contain searchable UniProt IDs and names, canonical and moonlighting functions, gene ontology (GO) numbers, plant species and links associated to the PubMed articles
Summary
Moonlighting proteins are single polypeptide chains capable of executing two or more distinct biochemical and/or biological functions. Many canonical domains in other organisms, including animals and bacteria that exist as stand-alone proteins, have been incorporated into multi-functional complex plant proteins often as smaller functional centers that are embedded within larger primary domains [13]. Current databases contain moonlighting proteins from human and other organisms, but plant moonlighters are under-represented.
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