Abstract
Crown galls develop on dicotyledonous plants after infection by Agrobacterium tumefaciens. In virulent agrobacteria a large plasmid which is called Ti-plasmid, carries the genetic information for oncogenicity. A fragment of this plasmid is present and is expressed in crown gall cells. The fragment is called T-DNA and it probably harbours the genes responsible for the neoplastic condition of the cells. It is assumed that the autonomous growth of crown gall cells is due to the activity of the hormones auxin and cytokinin in the cell. Ti-plasmid mutants, which induce tumours with different phenotype, have led to the supposition that T-DNA genes are responsible for both hormone activities.
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