Abstract
Bone regeneration (osteointegration) is an essential principle to analyze the accomplishment of implant treatment. This aim of current study was assessment of the osteoinductive potential and analgesic properties of the gold nanoparticles (Au NPs), which were fabricated utilizing Anogeissus latifolia (A. latifolia) phytochemicals. Green fabricated Au NPs showed an exceptional stability in different blood components like human serum albumin (2%), bovine serum albumin (2%), cysteine (0.2 M) and histidine (0.2 M). The bio fabricated Au NPs were also observed to be non-hazardous when tested for their blood compatibility and cytocompatibility by using erythrocytes and periodontal fibroblasts respectively. Au NPs showed greater cell viability percentage (138 ± 27.4) on exposure to MG-63 cell lines in comparison with control group (96 ± 3.7) confirming their osteoinductive potential. Further, analgesic activity studies revealed that a strong antinociperceptive activity was displayed by A. latifolia aqueous leaf extract and the formed Au NPs. In this study, it was concluded that the biocompatible, environmental friendly and stable Au NPs were utilized as an efficient analgesic property for pain management and as bone inducing agent in dental tissue implantation treatment in nursing care.
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