Plant Gum Aided Mucoadhesive Microspheres to Eradicate Helicobacter pylori and Its Optimization with Design-Expert's Central Composite Design

Abstract

Aim: The aim of the work was to explore the mucoadhesive properties of Mastic gum by involving it in mucoadhesive microspheres with Amoxicillin Trihydrate as a model drug. Using Carbopol-934P and varying amounts of Mastic gum. Methods: 9 interpretations of mucoadhesive microspheres were made by using Design expert software. A central composite design was applied to test the impact of independent variables (Carbopol-934P and mastic gum levels) on drug released at 10h and mucoadhesive strength as the response. Results: A congeniality and physical exam was conducted on the microspheres to see if Amoxicillin Trihydrate (ATH) was present, including its liberation. In formulations that contain lower levels of MG, mucoadhesion strength increased and drug released at the end of 10h was greater. Conclusion: Since MG acts as a release retardant, the amount of drug released is slightly reduced when higher levels are present in formulations. ATH gastro retention for eradicating with Mastic gum aided mucoadhesion (as this gum is proven H. pylori activity) is capable of completely capturing the gastrointestinal tract and effectively delivering the medication to the stomach.