Plant-food-derived bioactives: Key health benefits and current nanosystems as a strategy to enhance their bioavailability

Bahare Salehi,Farukh Sharopov,Beraat Í–Zçelik,Evren Demircan,Célia F Rodrigues,Gözde Gülseren,Aslı Can Karaca,Ezgi Åženol,Javad Sharifi-Rad,Alfred Maroyi,Sena Tutuncu,Natália Martins

doi:10.14715/cmb/2020.66.4.28

Abstract

Natural products interest is gradually increasing worldwide. Plant-food-derived bioactives have a long history of use as a good source of ingredients for valuable medical usages. Plant-based foods consist of micro and macronutrients, and bioactive components, with health-promoting benefits. The handling of complex mixtures of plants has been methodically switched by therapies using a single isolated substance. The delivery of bioactive molecules in nanosystems is enhancing their bioavailability, it is much safer and cost-effective. However, there are many challenges in combining bioactive substances in nanocarrier materials. A discussion related with nanocarriers will be done in this review.

Highlights

Nature-derived products, such as fruits, vegetables, wild plants and nuts can be processed into derived products [1]
People facing to chronic diseases have a high demand for healthier foods, which poses a challenging step to food industry [7]
The purpose of this study is to look for the variety of plant chemicals and their efficacy and bioavailability, according to the published literature

Summary

Introduction

Nature-derived products, such as fruits, vegetables, wild plants and nuts can be processed into derived products [1]. Vegetables and whole grains are sources of these secondary metabolites This group of compounds include a heterogeneous class of molecules with different chemical structures and hydrophilic or lipophilic units [29]. The polysaccharide coating material is slightly sensitive, stablishing with bioactive core and forming complex products under extreme conditions, like high temperature or pressure (i.e. Maillard reaction products), being potentially toxic but may trigger bioactive substances depletion [99] These polysaccharide materials are classified into polyelectrolytes containing anionic, cationic and neutral subtypes, and non-polyelectrolytes, that despite are biocompatible, have been applied on polysaccharide nanoparticles development, interacting with specific receptors in cells and tissues, ensuring a site-specific controlled targeting for components carried in polysaccharide-based nanoparticles [100]. Lipid Nanocarrier Systems Lipid-derived systems have been used to encapsulate bioactive substances, with liposphere and liposome being the most common, liposome is more commonly used than liposphere, being less applied for food application systems due to its very high level of

Methods

Findings

Future Prospects and Conclusion