Abstract
Plant expression systems could be used as biofactories of heterologous proteins that have the potential to be used with biopharmaceutical aims and vaccine design. This technology is scalable, safe and cost-effective and it has been previously proposed as an option for vaccine and protein pharmaceutical development in developing countries. Here we present a proposal of how plant expression systems could be used to address Zika and chikungunya outbreaks through development of vaccines and rapid diagnostic kits.
Highlights
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The laboratory confirmation of Zika, dengue or chikungunya infection is important because each one has different implications for follow-up both in the short and long term
There are Zika and chikungunya vaccines under development, but current vaccine production is compromised by reduced capacity of vaccine manufacturers and substantial unmet needs for investment[7]
Summary
After the arrival of Zika and chikungunya viruses to Latin American countries, they quickly became endemic diseases They currently pose an acute and chronic burden for health systems and represent a diagnostic challenge in areas where those infections co-circulate with dengue and other febrile-illnesses[5,6]. Efficiency and effectiveness, transformation using A. tumefaciens has been the preferred method for biopharmaceutical protein production This method does not require special equipment like the gene gun, it allows a more precise and selective transgene insertion, and results in lower tissue damage and higher available biomass for protein production.
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