Abstract
We have recently demonstrated that the exopolysaccharides (EPSs) produced by a plant-derived lactic acid bacterium, Lactobacillus paracasei IJH-SONE68, prevent and ameliorate allergic reaction on contact in dermatitis model mice. In the present study, we conducted a clinical trial using a capsule containing spray-dried powder from pineapple juice broth fermented with the LAB strain as an experimental diet. The clinical trial was conducted as a double-blind and placebo-controlled randomized comparative study from May 2019 to July 2021. Males and females between the ages of 21 and 70 who experience chronic allergies participated in the study. Sixty subjects were instructed to orally take a capsule containing the IJH-SONE68 powder or placebo, every day for 12 weeks. After the clinical trial was over, the scores based on subjects’ self-assessment of allergic status were significantly improved in the intervention group, as compared with the placebo group. Some serum biochemicals associated with inflammation response were also significantly improved by intake of the experimental diet. In conclusion, the IJH-SONE68-derived EPS improves chronic allergy status in humans and is expected to decrease their inconvenience.
Highlights
Allergic diseases are immunoglobulin E (IgE)-mediated type I inflammatory disorders, including allergic rhinitis [1,2]
Allergic rhinitis is manageable with appropriate treatment but resists cure; the treatment is aimed at alleviating symptoms and removing difficulties to improve patients’ quality of life (QOL) [6]
The items and scores were designed according to the criteria previ(2) a score of 40 or above for the visual analogue scale (VAS) value, indicating difficulty ously developed in guidelines
Summary
Allergic diseases are immunoglobulin E (IgE)-mediated type I inflammatory disorders, including allergic rhinitis [1,2]. The major symptoms of allergic rhinitis are sneezing, nasal congestion, and lacrimation caused by complex allergen-driven mucosal inflammations, and the increased inflammatory mediators lead to sensory nerve activation, plasma leakage, and congestion [3,4]. The prevalence of these diseases in the USA ranges from 9 to 42%, and in the UK, it reaches 26% in adults [1,5]. The LABs are generally non-pathogenic and many strains of them produce functional substances that have health benefits for humans [8,9]
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