Abstract
Plant Based Edible Vaccines against Poultry Diseases: a Review
Highlights
Infectious diseases are a major threat to the poultry industry
The major pitfalls of existing vaccines are high production cost, difficulty in maintaining cold chain, vaccine safety, problems associated with mass vaccination, manpower and technical skill needed for vaccine administration, complexity in production and purification etc (Nochi et al, 2007; Ferraro et al, 2011; Klein et al, 2013) (Figure 1)
First plant expression of a vaccine antigen was done by Dr Curtiss and Dr Cardineau in 1990 against Streptococcus mutans which is the causative organism for dental decay in humans
Summary
Infectious diseases are a major threat to the poultry industry. Economic losses due to poultry diseases are 10 to 20% of the gross value of production in developed countries and are likely to be higher in developing countries (FAO, 2014). With the advent of transgenic technology, development of plant based edible vaccines offers a new prospect to overcome these hurdles. Other advantages of plant based vaccines are ease of production, scale up and administration, biological encapsulation of candidate antigen, ability to evoke serum and mucosal response, protection against mucosal pathogens, low production cost, room temperature stability, trouble free storage, devoid of human or animal pathogens, free from pyrogens and microbial toxins, needle free administration etc. Plant Based Edible Vaccines against Poultry Diseases: a Review.
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