Planning, Synthesis, and Pharmacological Activity of Alkyl Derivatives of 3-Mercapto-4-Phenyl-5-Arylaminomethyl-1,2,4-Triazole-(4H)

Abstract

The targeted synthesis of biologically active substances in a series of 4-phenyl-5-phenylaminomethyl-1,2,4-triazol-(4H)-3-ylmercaptoacetic acid anilides was planned. Subsequent pharmacological screening was planned using computerized prediction of the potential pharmacological activity. Target products were synthesized by alkylation of key intermediates, i.e., 4-phenyl-5-arylaminomethyl-3-mercapto-1,2,4-triazole-(4H) chloroacetic acid anilides. The structures of the compounds were confirmed by elemental analysis and PMR spectroscopy. Pharmacological screening results identified subjects with high levels of analgesic activity, comparable to that of Analgin, among the study compounds. Compounds had moderate anticonvulsive activity, but less than that of lamotrigine.