Abstract
This study presents a methodology of integrating dielectrophoresis (DEP) and electrorotation (ROT) on to a planar open electrode system platform to combinatorially characterize and separate organic and inorganic micro particles separate We have optimized methods to develop “biochip” prototype device that is easy to fabricate with an electrode geometry that enables unique combination of programmed input electrical signals that induces DEP and ROT simultaneously for micro-particle separation. We have demonstrated the isolation of target organic/inorganic particles from a heterogeneous sample population using dynamic DEP and ROT induced electric fields. Target particles were effectively separated and simultaneously analyzed for its dielectric properties using dynamic electrode geometry. In this study we have successfully shown the separation of two study models with separation efficiency of >96% from heterogeneous mixture of organic (HeLa and HEK cells) and inorganic (polystyrene beads) particles as a proof-of-feasibility suitable for translation research.
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