Abstract
Official journal of the Postgraduate Institute of Medicine, University of Colombo, Sri Lanka.Interested in submitting to this journal? We recommend that you review the About the Journal page for the journal's section policies, as well as the Author Guidelines. Authors need to register with the journal prior to submitting or, if already registered, can simply log in and begin the five-step process.
Highlights
Cardiac amyloidosis is an uncommon cause of heart disease resulting in restrictive cardiomyopathy [1,2,3]
The data were evaluated according to a published standard for planar scans (Perugini scale) and single photon emission computed tomography (SPECT)/computed tomography (CT) imaging which visually demonstrated any cardiac uptake in the 1 hour or 3 hour scans were taken into account
Positivity for cardiac amyloidosis was assumed from the amyloid clinic working diagnosis, other imaging findings, cardiac assessment, and available cardiac biopsy histology results
Summary
Cardiac amyloidosis is an uncommon cause of heart disease resulting in restrictive cardiomyopathy [1-,2,3] It is a recognized cause of increased morbidity and mortality in the restrictive cardiomyopathy group due to difficulties in treatment [1,4,5]. Amyloid deposition in the heart muscles results in cardiac dysfunction leading to heart failure [1,2]. ATTR is assessed with planar images using Technetium (Tc)-99m-3,3diphosphono-1,2-propanodicarboxylic acid (DPD) scans. The sensitivity, specificity and diagnostic accuracy of the planar and SPECT/CT DPD scans were 88.2%, 100% and 96.2%, respectively. Five equivocal studies in the Planar and SPECT/CT scan were positive by other imaging methods or biopsy. Good cardiac function with a New York Heart Association (NYHA) assessment of 1 and 2 and good ejection fraction (EF) was noted in 73% of patients with DPD planar positive cardiac amyloidosis
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