Abstract
Plague is a zoonotic disease, normally circulating in rodent populations, transmitted to humans most commonly through the bite of an infected flea vector. Secondary infection of the lungs results in generation of infectious aerosols, which pose a significant hazard to close contacts. In enzootic areas, plague infections have been reported in owners and veterinarians who come into contact with infected pets. Dogs are relatively resistant, but can import infected fleas into the home. Cats are acutely susceptible, and can present a direct hazard to health. Reducing roaming and hunting behaviours, combined with flea control measures go some way to reducing the risk to humans. Various vaccine formulations have been developed which may be suitable to protect companion animals from contracting plague, and thus preventing onward transmission to man. Since transmission has resulted in a number of fatal cases of plague, the vaccination of domestic animals such as cats would seem a low cost strategy for reducing the risk of infection by this serious disease in enzootic regions.
Highlights
Yersinia pestisPlague is caused by the bacterial pathogen Yersinia pestis, a Gram-negative non-motile, non-spore-forming coccobacillus
Simple Summary: Plague is a notorious disease of humans, typically transmitted from rodents to man by the bite of infected fleas
Y. pestis appears to have passed through an evolutionary bottleneck and in its relatively isolated niche is unable to restore the array of pseudogenes it possesses
Summary
Plague is caused by the bacterial pathogen Yersinia pestis, a Gram-negative non-motile, non-spore-forming coccobacillus. It is capable of growth between 4 and 40 °C, but grows optimally at. Nowadays biovar Antiqua strains are isolated in Africa, and may be descended from the bacteria that caused the first pandemic. Y. pestis appears to have passed through an evolutionary bottleneck and in its relatively isolated niche is unable to restore the array of pseudogenes it possesses. It is probably in an evolutionary dead-end
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