Placental transmission of cytotoxicantibody in rabbits with maternal-fetal homograft incompatibility

Abstract

several mothers. This material by our method of quanti tat ion had a B~A concentration some 33 times that of normal adult serum, and enough was given to raise the serum level of the infant about fiftyfold. However, there was no effect on the serum level and it would appear that none was absorbed. DR. HonEs. Was this the first thing the baby was fed ? DR. Wes r l The infant was 41 hours old at the time the colostrum was fed and feedings had been instituted. The colostrum was given 2 89 hours after the last feeding. DR. MARGARET MACGILLIVRAY, Massachusetts General Hospital, Boston 14, Mass. I wanted to ask if antibody against serum beta-2A component which is 7S globulin cross-reacted with the colostrum beta-2A? DR. HODES. In answer to Dr. West, we did not test the beta-2A antibody which we isolated for the presence of complement. Regarding the absorption of colostrum beta-2A polio antibody from the intestine into the blood, we just haven ' t enough data to give a clear answer. I think several conditions have to be fulfilled before we can be certain on this point. We must be certain that: (1) the baby gets eolostrum as the first feeding; and (2) large quantities are fed so that passage of the antibody can be detected. We expect to be able to give a definitive answer very soon, In answer to Dr. MacGillivray, we do not have an antibody made against the beta-2A globulins of normal serum. However, we do have antiserum made against myeloma beta-2A globulins. This antiserum reacts with eolostrum beta-2A globulins. This means that coIostrum beta-2A globulins and myeloma beta-2A globulins have common antigenic determinants; it does not necessarily mean that they are identical. As Dr. MacGillivray has said, most serum beta-2A globulins are 7S globulins, while colost rum beta-2A globulins are 1 IS. In any case, there is no polio antibody in the serum beta-2A globulins.