Abstract
The present study was designed to determine the rate of placental transfer of imipramine (Tofranil), an antidepressive agent which is widely distributed in tissues. It was also designed to determine the time required for the establishment of equilibrium between the maternal and fetal systems. Twenty rats which were in the third trimester of pregnancy received an intramuscular injection of 10 mg. per kilogram of imipramine. The animals were killed at 1, 3, 5, 10, and 20 minute intervals by exsanguination, and the concentration of the drug in the maternal plasma and fetal tissue determined. Equilibrium between the two systems was established within 3 minutes. It was suggested that this rapid equilibrium between the maternal and fetal systems was due to the high lipid solubility of imipramine.
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