Abstract
Placental site trophoblastic tumor (PSTT), a rare form of gestational trophoblastic disease (GTD) has a wide clinical and biological spectrum with benign to malignant potential. PSTT can occur after any type of pregnancy and no specific risk factors have been established. Mitotic index is the most important prognostic factor in determining the outcome of disease. Though early and benign disease is cured with surgery, for advanced metastatic disease, chemotherapy plays an important role in management. However, chemotherapy resistance is a main obstacle in achieving adequate control in patients with advanced disease. This article reviews the literature on this rare disease and tries to provide a comprehensive view on its management.
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