Abstract

Placental Site Nodule (PSN): An Uncommon Diagnosis with a Common Presentation

Highlights

  • Placental site nodule (PSN) is a rare, benign lesion which represents remnants of intermediate trophoblast from a previous gestation that has failed to completely involute [1,2,3]

  • These lesions are discovered as incidental findings in curettage or hysterectomy specimens performed for evaluation of irregular uterine bleeding, abnormal cervical smears, post coital bleeding etc. [1,4,5]

  • PSN needs to be differentiated from aggressive lesions of intermediate trophoblast like placental site trophoblastic tumor and epithelioid trophoblastic tumor and from nontrophoblastic diseases like squamous cell carcinoma [1,4]

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Summary

Introduction

Placental site nodule (PSN) is a rare, benign lesion which represents remnants of intermediate trophoblast from a previous gestation that has failed to completely involute [1,2,3]. Placental site nodule is an uncommon, benign, generally asymptomatic lesion of trophoblastic origin, which may often be detected several months to years after the tenancy from which it resulted. PSN is benign, but it is important to distinguish it from the other benign and malignant lesions like decidua, placental polyp, exaggerated placental site and placental site trophoblastic tumor and squamous cell carcinoma.

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