Abstract

Background and aims Particulate matter exposure during in utero life may entail adverse health outcomes later in life. Epidemiological studies in adults have linked air pollution’s adverse effects to alterations in gene expression profiles, which can be regulated by epigenetic mechanisms, including microRNAs (miRNAs). MiRNAs have been implicated in diverse biological processes. We investigate the potential influence of air pollution exposure in early life on placental miRNA expression.

Highlights

  • Background and aimsParticulate matter exposure during in utero life may entail adverse health outcomes later in life

  • Epidemiological studies in adults have linked air pollution’s adverse effects to alterations in gene expression profiles, which can be regulated by epigenetic mechanisms, including microRNAs

  • MiRNAs have been implicated in diverse biological processes

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Summary

Introduction

Particulate matter exposure during in utero life may entail adverse health outcomes later in life. Epidemiological studies in adults have linked air pollution’s adverse effects to alterations in gene expression profiles, which can be regulated by epigenetic mechanisms, including microRNAs (miRNAs). MiRNAs have been implicated in diverse biological processes. We investigate the potential influence of air pollution exposure in early life on placental miRNA expression

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