PLACENTAL HISTOPATHOLOGY CORRELATION WITH ANTENATAL UMBILICAL AND UTERINE ARTERY DOPPLER

Abstract

Defective placentation results in a host of pregnancy complications like fetal loss, preeclampsia, and fetal growth restriction and abruptio placentae. There have been recent major advances in obstetric ultrasound such as high-resolution antenatal structural imaging, determination of maternal and fetal blood ow parameters and 3D and 4D ultrasound, which have revolutionised the obstetric care by antenatal diagnosis of placental pathology and its effect on the fetuses. The aim of this study is to correlate placental pathology ndings to antenatal Doppler and ultrasonogram and fetal outcome. : All placental specimens received in the department of Pathology, Karnataka Institute of MedicalMETHODS sciences, Hubballi from October 2017 to March 2019 were collected after taking an informed consent. All the casesINCLUSION CRITERIA: with antenatal Doppler and ultrasonogram details, irrespective of the gestational age and fetal outcome. UnbookedEXCLUSION CRITERIA: cases and cases without clinical history and image ndings. 115 cases Gross examination was done and sections were takenSAMPLE SIZE: from parenchyma, umbilical cord and the membranes according to Amsterdam guidelines for microscopic examination. The resultant microscopic ndings were correlated with antenatal Doppler and ultrasonogram. 115 of the 539 cases included in this study had Doppler data,RESULTS: among them, 19 cases showed abnormal Doppler. Placentae with abnormal Doppler ndings showed increased syncytial knots, poor vasculo- syncytial membrane, villous crowding and infarct (p<0.05) and were associated with increased fetal death and growth restriction. CONCLUSION: Placental study correlated with the Doppler ndings and was instrumental in reaching a specic diagnosis in inconclusive cases.