Placental and serum production of cytokines and relaxin in pregnant women with diabetes mellitus

I I Krukier,A S Degtyaryova,A V Rozhkov,A A Nikashina,V V Avrutskaya,A A Grigoriants

doi:10.33667/2078-5631-2019-3-25(400)-43-45

I I Krukier, A S Degtyaryova + Show 4 more

Open Access

https://doi.org/10.33667/2078-5631-2019-3-25(400)-43-45

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Abstract

Objective of research was to study the production of serum and placental cytokines and relaxin in women with a physiological pregnancy (45) and complicated by type I diabetes mellitus (42). The research material was the placenta and serum of pregnant women, in which determined the level of cytokines TNF-α, TGF-β, IL-1β and relaxin. It has been shown that the cytokine-producing function of the placenta plays an important role in the development of that organ, and systemic production of cytokines and relaxin is of key importance in the development of endothelial dysfunction syndrome. Early diagnosis of complications in pregnant women with type 1 diabetes will make it possible to start etiopathogenetic therapy in a timely manner and makes it possible to perform adequate obstetric tactics of labor.

Highlights

Summary Objective of research was to study the production of serum and placental cytokines and relaxin in women with a physiological pregnancy (45) and complicated by type I diabetes mellitus (42)
The research material was the placenta and serum of pregnant women, in which determined the level of cytokines TNF-α, TGF-β, IL‐1β and relaxin
It has been shown that the cytokine-producing function of the placenta plays an important role in the development of that organ, and systemic production of cytokines and relaxin is of key importance in the development of endothelial dysfunction syndrome

Summary

Introduction

Плацентарная и сывороточная продукция цитокинов и релаксина у беременных с сахарным диабетом Ростов-на-Дону 2ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава России, г. Placental and serum production of cytokines and relaxin in pregnant women with diabetes mellitus Резюме Целью работы явилось изучение продукции сывороточных и плацентарных цитокинов и релаксина у женщин с физиологической беременностью (45) и беременностью, осложненной сахарным диабетом (СД) первого типа (42).

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Conclusion