Abstract
The role of glucan in stimulation of immune reactio ns has been well-established. In this report, we fo cused on the antibody production in glucan-supplemented children with chronic respiratory problems. We measured the levels of salivary IgA, IgM and IgG in 40 children aged 8-12 years and evaluated the effe cts of 100 mg d -1 oral dose of glucan. We found a significant increa se in production of all tested antibodies in the glucan-stimulated group, but a decrease of anti body production in the control group. A thirty-day oral application of yeast-based natural immunomodulator β-glucan strongly stimulated the mucosal immunity of children with chronic respiratory problems.
Highlights
Japan has sucessfully used several forms of mushroomderived β-glucan in cancer patients (Hamano et al, 1999).Upper respiratory infections are the highestNumerous rodent studies demonstrated that glucan incidence of acute illness in the developed world
We focused on the antibody production in glucan-supplemented children with chronic respiratory problems
We found a significant increase in production of all tested antibodies in the glucan-stimulated group, but a decrease of antibody production in the control group
Summary
Japan has sucessfully used several forms of mushroomderived β-glucan in cancer patients (Hamano et al, 1999).Upper respiratory infections are the highestNumerous rodent studies demonstrated that glucan incidence of acute illness in the developed world. Japan has sucessfully used several forms of mushroomderived β-glucan in cancer patients (Hamano et al, 1999). Numerous rodent studies demonstrated that glucan incidence of acute illness in the developed world. The average adult has 3 colds per year and the average schoolchild up to 10 (Spector, 1995; Vetvicka and Vetvickova, 2010). Patients with complications may benefit from antibiotic or inhaler treatment, current medicine has very little to offer for uncomplicated infections. There is no doubt that a need for effective, safe and inexpensive treatment of chronic respiratory problemsexists. Our paper is focused on the natural immunomodulator β-glucan as a possible solution
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