Abstract
This study evaluated the effects of naltrexone treatment for adults with mental retardation and self-injury across, a selection of dose levels, target behaviors, subjects and treatment phase durations. Statistical analysis of group results revealed a significant reduction in self-injury rate during naltrexone treatment. However, analysis of single-subject data indicated that only two of the nine subjects assessed demonstrated a significant and maintained suppression of self-injury rate associated with naltrexone treatment. The positive response of these two subjects occurred at the higher naltrexone dose level (100 mg/day) and appeared to be related to increased bioavailability of 6-beta-naltrexol, the active metabolite of naltrexone. Four subjects demonstrated naltrexone-related reductions in stereotypy, and one subject demonstrated naltrexone-related increases in adaptive material interaction. Given the wealth of previous research on naltrexone treatment of self-injury, present findings are discussed in relation to those of previous studies that have found more positive results.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Developmental and Physical Disabilities
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
