Abstract
AbstractOral fluid testing is of real interest for monitoring drugs of abuse in driving under influence of drugs (DRUID), workplace drug testing, therapeutic drug monitoring, clinical toxicology and postmortem toxicology, possibly in addition to blood or urine. Collection of saliva is easy, non-invasive, and can be performed by non-medical personnel. For the past 20 years, point-of-collection testing devices and confirmation methods more sensitive and specific are more reliable. However, confirmation of positive tests by chromatographic techniques coupled with mass spectrometry remains essential. Interpreting the results must take into account many factors (intra- and inter-individual variabilitie, method of saliva collection, reliability of tests, passive contamination…) that the toxicologist must keep under control.
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