Abstract
Hydrogen sulfide (H 2 S) emerged recently as an important signaling molecule involved in regulation of blood pressure and neuronal activity. Additionally, H 2 S and its donors possess huge pharmacological potential to prevent ischemia–reperfusion injuries and, as it has been speculated, to induce suspended animation-like state in small animals. However, the real (bio) chemical events behind all these observed phenomena remained elusive. In this talk, physiological effects of H 2 S in context of its interaction with another physiological gassotransmitter, nitric oxide (NO), and its metabolites (peroxynitrite, S-nitrosothiols, nitrite) will be addressed, providing the evidence for the existence of a strong cross-talk of these molecules. Applying state-of-the art analytical techniques, as the products of these reactions, we identify thionitric (HSNO 2 ) and thionitrous acid (HSNO) as well as nitroxyl (HNO), and show on cellular level that they too serve as important signaling molecules. Finally on the animal level we prove our chemistry and show that H 2 S-induced vasodilatory effects are directly NO dependent, identifying therefore completely new signaling cascade for systemic neurovascular control.
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