PKNOX2 regulated by TGFbeta is a new candidate to explain bone marrow failure in fanconi anemia

Abstract

Authors: Though bone marrow transplantation is the current option of Fanconi aplastic anemia treatment, an improved understanding of hematopoietic stem cells (HSCs) exhaustion in Fanconi anemia (FA) may open the way of new therapeutic strategies. Our work has focused on the cross talk between mesenchymal stem cells (MSCs) and HSCs in FA. Coexistence of developmental malformations in FA, first raised the question of a possible interaction of FA proteins with developmental proteins. Expression of genes encoding HOX/TALE transcription factors starts early in development and their defects can cause developmental malformations.