Abstract
PKA modulation of Rac in neuronal cells.
Highlights
The Rho-family GTPase, Rac, is a molecular switch that controls actin dynamics and thereby the morphology, migration, and cytokinesis of most, if not all, cell types (Heasman and Ridley, 2008)
The direct upstream input to Rac comes from guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (Figure 1A)
Protein kinase A (PKA) is a good candidate for such a serine/threonine kinase; there have been no direct demonstrations of PKA regulation of GEFs for Rac, except for a few examples, in neuronal cells
Summary
The Rho-family GTPase, Rac, is a molecular switch that controls actin dynamics and thereby the morphology, migration, and cytokinesis of most, if not all, cell types (Heasman and Ridley, 2008). These observations suggest that PKA may regulate Rac to induce s a number of morphological changes. Among the more than 60 Dbl-family GEFs, Tiam1, STEF/Tiam2, P-Rex1, and Vav3 have been shown to regulate the migration of neuronal progenitor cells and neurite extension of neurons (Govek et al, 2011).
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