Abstract
Background The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Accordingly, endothelial dysfunction underpins many cardiovascular diseases, including hypertension, myocardial infarction and stroke. C-type natriuretic peptide (CNP) is a paracrine mediator that possesses a unique vasoand cardioprotective pharmacodynamic profile; however, there is a paucity of information regarding a physiological role for CNP within the cardiovascular system.
Highlights
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets
C-type natriuretic peptide (CNP) is a paracrine mediator that possesses a unique vaso- and cardioprotective pharmacodynamic profile; there is a paucity of information regarding a physiological role for CNP within the cardiovascular system
These data identify a mechanism explaining genome-wide association studies linking the natriuretic peptide receptor (NPR)-C (Npr3) and Furin loci with hypertension, and establish the importance of CNP-NPR-C signalling in preserving vascular homoeostasis and as a disease-modifying drug target
Summary
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP) From 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications Trier, Germany.
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