Pityriasis Rubra Pilaris Transcriptomics Implicate T Helper 17 Signaling and Correlate with Response to Ixekizumab, with Distinct Gene Expression Profiles in Nonresponders

Abstract

Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disorder associated with significant patient morbidity (Eastham et al., 2019, Ji-Xu et al., 2022). Recent discoveries in the pathophysiology of PRP—including alterations in IL17 signaling (Feldmeyer et al., 2017, Haynes et al., 2020, Strunck et al., 2022, Boudreaux et al., 2022), phospholipase A2 processing (Shao et al., 2021), and novel germline CARD14 genetic variations (Fuchs-Telem et al., 2012)—have yielded new diagnostic and therapeutic insights.