Pityriasis Rubra Pilaris Response to IL-17A Inhibition Is Associated with IL-17C and CCL20 Protein Levels

Abstract

Pityriasis rubra pilaris (PRP) is a rare, severe inflammatory skin disease associated with high morbidity and debilitating effects on QOL (Eastham et al., 2019; Ross et al., 2016). Classical features include follicular hyperkeratosis; erythematous plaques often progressing to erythroderma with islands of sparing; and waxy, palmoplantar keratoderma. The pathogenesis and etiology of PRP remain poorly understood. Small case series have shown dysregulation of the IL-23/IL-17 axis (Adnot-Desanlis et al., 2013; Feldmeyer et al., 2017; Nagai et al., 2020).