Abstract
The therapeutic outcome of cisplatin is limited due to its adverse side effects in normal tissues. Despite its potent antineoplastic effect, cisplatin is known by a relevant collateral action, for instance, acute renal failure. The aim of this study was to assess the effectiveness of Pituranthos chloranthus (PC) essential oil for contracting cisplatin-induced toxicity, in Balb/c mice. The standard mouse model of cisplatin-induced acute kidney injury (AKI), consisting of one intraperitoneal injection of cisplatin (20 mg/kg), was adopted. Mice were pretreated by intraperitoneal administration of PC (5 and 10 mg/Kg b.w) for one week. Cisplatin induced alteration in renal and liver functions, evidenced by increased serum biomarkers levels (creatinine, ALT, and AST). Significant mitigation of cisplatin-induced toxicity was confirmed by lowered levels of serum biomarkers and reduced DNA damage in liver and kidney. PC also restored the alterations in oxidative stress markers and proinflammatory cytokine IFN-γ level. Overall, this study provides, for the first time, that PC can be applied as an antioxidant-adjuvant treatment to mitigate cisplatin-induced renal failure.
Highlights
Cisplatin is one of the options that is gaining interest in clinical oncology, since it has shown effectiveness against various types of cancers [1]
Cisplatin injection led to a dramatic loss in the average bodyweight, by 16 %
To confirm the harmful effect of cisplatin on the kidney and spleen and to investigate whether Pituranthos chloranthus (PC) exerts any protective effect on these organs, the organosomatic index was determined at the end of the experiment
Summary
Cisplatin is one of the options that is gaining interest in clinical oncology, since it has shown effectiveness against various types of cancers [1]. Cisplatin-induced nephrotoxicity can cause an acute kidney injury (AKI), occurring in 20–30% of patients [2]. E mechanism of cisplatin-induced nephrotoxicity is a complex process involving oxidative stress, genotoxicity, and inflammation. Some of suggested strategies have been implemented to diminish or prevent nephrotoxicity of cisplatin. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds. The application of amifostine is limited due to its side effects, cost, and concerns about possible interference with the antitumor activity of cisplatin [8]. Natural antioxidants have been known to impart protection without compromising the antitumor potential of chemotherapeutic drugs and side effects erefore, studies on screening of potential
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