Abstract
Hyponatremia in panhypopituitarism is multifactorial, it can be explained by the corticotropic deficit observed in pituitary insufficiency which is responsible for a lifting of inhibition on the anti-diuretic hormone with a consequent net reduction of water excretion, Hypothyroidism is also cited as a contributing mechanism for the development of acute hyponatremia in pituitary insufficiency through reduced free water excretion. Hyponatremia as a mode of revelation remains rare, we report a case of severe hyponatremia revealing pituitary insufficiency on pituitary macroadenoma.
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